PhD Studentship

3.5 year, full-time PhD studentship

Project title: Baculovirus P10 and microtubules; the role of P10 in virus-induced nuclear lysis with possible applications for novel anti-cancer therapies

Eligibility: Home UK/EU applicants who must be permanently resident in the UK/EU

Closing date: 20 March 2020

Start date: September 2020

Bursary p.a.: equivalent to UKRI national minimum stipend plus fees (2019/20 rate is £15,009)

University fees and bench fees at the Home/EU rate will be met by the industrial sponsor, Oxford Expression Technologies Ltd, for the 3.5 years of the Studentship.

Supervisors: Prof Linda King, Dr Victor Bolanos-Garcia and Dr Adam Chambers

Project:

Baculoviruses are insect-specific viruses that have a fascinating, two-phase replication cycle that in phase one results in the release of budded virus to spread the infection between cells whether in insect larvae or in cultured insect cells.  In phase 2, virus particles remain in the nucleus where they become embedded in a proteinaceous matrix to form polyhedra.  Polyhedraare released from nuclei following nuclear lysis or disintegration and serve to protect virus particles during horizontal transmission between larvae.

This project aims to (1) understand the mechanisms involved in baculovirus-induced nuclear lysis to release polyhedra-containing virus particles; (2) investigate the role of cellular microtubules and viral protein P10 in this process through molecular, structural biology and microscopy techniques; and (3) investigate the possibility that by disrupting microtubules, P10 could be developed as a novel anti-mitotic therapeutic in cancer cells. The project would ideally suit an outstanding graduate with a strong interest in the study of virus-host interactions and/or molecular mechanisms of cell division regulation.  Training and experience will be provided in a range of modern bioscience techniques including cell culture, virology, molecular biology, structural biology and microscopy

We are seeking a motivated and talented student to join our multi-disciplinary team working in an excellent research environment in modern well-equipped laboratories, which is in collaboration with Oxford Expression Technologies Ltd (OET), a small biotech company conveniently located within Oxford Brookes Bioinnovation Hub.For further information contact Prof Linda King: laking@brookes.ac.uk or Dr Victor Bolanos-Garcia: vbolanos-garcia@brookes.ac.uk

Requirements:
Applicants should have a first or upper second class honours degree from a Higher Education Institution in the UK or acceptable equivalent qualification in Biological Sciences or a related discipline. Some experience in lab-based experimental design, execution and analysis is essential. EU applicants must have a valid IELTS Academic test certificate (or equivalent) with an overall minimum score of 7.0 and no score below 6.0 issued in the last 2 years by an approved test centreunless unless they have completed a degree in English.

How to apply:
Applications should be sent to hlsapplications@brookes.ac.uk and should include the following form (http://www.hls.brookes.ac.uk/images/research/phd-studentship-application-form-jan-14.doc)