News & Press

Baculovirus Transfer Vector Plasmid Compatibility

A frequent customer query concerns baculovirus transfer vector plasmid compatibility with either flashBACTM or other systems for making recombinant viruses.  Obviously, if you are buying flashBACTM and our pOET range of transfer vectors you won’t have a problem.  However, given that baculovirus expression vectors have been around since 1983 and many labs have produced variations around a theme, it is not surprising that confusion can arise. Most baculovirus expression vectors

Pre-GMP Manufacture of Recombinant Proteins

While OET is currently unable to offer GMP manufacture of recombinant proteins or viruses, we can offer a premium service for pre-GMP manufacture.  This can serve as a very useful bridge to full GMP projects conducted by other service providers.  So what is the advantage of a pre-GMP step? It really boils down to cost.  Some of our own R&D is moving in the direction of needing GMP but we

OET Visits Key Partners in Mexico for Diabetes Type I Research

OET scientists, Dr Mine Aksular and Dr Leo Graves, recently travelled to Mexico City to spend six days visiting the Centre for Molecular and Cell-Based Therapeutics (CMCBT) as part of an international research collaboration (TRANSDIA) investigating a novel therapy for type I diabetes. Accompanied by collaborator Dr Stephen Hughes from the Nuffield Department of Surgical Sciences, Oxford University, the team were able to provide expert advice and practical guidance on

OET Presenting at South Wilts Virus Group Annual Meeting

OET will be sponsoring and presenting at this year’s South Wilts Virus Group (SWVG) annual meeting on Thursday 24th May. The event, hosted by Oxford Brookes University Department of Biological and Medical Sciences, will allow OET scientists to exhibit our current research achievements and network with other specialists in the virology field. The SWVG is a forum for virologists in the Wiltshire/Surrey/Berkshire/ Oxfordshire region. The organisation originally began in 1952

OET is Awarded £2 Million Vaccine Development Contract

Oxford, UK – 4th May 2018   Oxford Expression Technologies Ltd (OET) is pleased to announce that it has been awarded a £2M contract from Innovate UK as part of the ‘Vaccines for Global Epidemics’ Round 2 competition. The award will allow OET to continue its ongoing work in developing the first economically viable vaccine against Crimean Congo Haemorrhagic Fever (CCHF) virus. The Vaccines for Global Epidemics competition supports the

Product Launch – pOET8!

November marks the welcome of OET’s newest product – the pOET8 baculovirus transfer vectors (pOET8.VE1; pOET8.VE2; pOET8.VE3).  Compatible with any baculovirus expression system, including our own flashBACTM technology, the new range of pOET8 vectors are proven to help increase recombinant protein production in insect cells. The increased yield is achieved by allowing co-expression of foreign genes with a vankyrin expression cassette.  This gene cassette comprises the Campoletis sonorensis ichnovirus P-vank-1 protein

baculoQUANT™ Titration of Recombinant Baculoviruses

There are many methods available for the titration of recombinant baculoviruses.  One of the most convenient is the use of the quantitative polymerase chain reaction (QPCR), which assesses how much virus DNA is present in a freshly-amplified stock.  This is compared with a standard curve derived from a control virus stock to give an infectious titre expressed as Q plaque forming units (pfu) per millilitre.  OET Ltd market the baculoQUANT™

flashBAC™ 5+1 offer

OET’s flashBAC™ 5 reaction kit ranges are some of our most popular products. However, recent feedback has revealed that some customers are reluctant to make use of the positive control transfer vector as this sacrifices 1 reaction and so reduces the number of their own viruses that they can produce. In recognition of this issue, until further notice, we are increasing the amount of flashBAC™ DNA in all of our

OET at ISBioTech Washington 6-8th March

OET founders, Linda King and Bob Possee will be attending ISBioTech in Washington, 6-8th March 2017.  Linda will be presenting a talk entitled, “BacMam Expression Vectors: Applications in Gene Therapy”.  The use of BacMAMs for recombinant gene expression in mammalian is an ever expanding application of baculovirus vectors.  Her talk will encompass some of her research group’s recent work on the potential use of BacMams to transduce whole organs and

TRANSDIA – Oxford Brookes University Press Release

Read the below the press release from Oxford Brookes University about the inaugural meeting for our joint project between UK-Mexico on diabetes type 1. Full article available here.   Brookes part of UK-Mexico collaboration to tackle type 1 diabetes Thursday, 03 November 2016 Oxford Brookes’ Pro Vice-Chancellor for Research and Global Partnerships, Professor Linda King visited Mexico last month (25-27 October) to be part of the official launch of the

Bac to our Roots!

Ever wondered where the baculovirus insect cell expression system came from? The clue is in the name – of course it came from viruses that naturally infect insect caterpillars or larvae and can cause a nasty lytic disease.  The symptoms are quite dramatic! You may not realise it, but insects are prone to all manner of diseases caused by a variety of pathogens including: viruses, bacteria, fungi, microsporidia, nematodes and

Virus Like Particles VLPs for Therapeutics and Research

Oxford Expression Technologies (OET) is now able to apply its flashBAC™ baculovirus expression system to vaccine production, particularly in the exciting new field of virus like particle (VLP) vaccines. A virus like particle is an assembly of virus structural proteins that mimics the configuration of a real virus, except that it contains no genetic material. If a person is vaccinated with VLPs then an immune response is generated as if

“Global Success” Says Oxford Brookes University

A glowing impact case study by Oxford Brookes University highlights the benefits and hard work we have put into to developing a unique and advanced protein production system, labeling OET as a global success in the field of baculovirus research. Read below to find out more or click here to view the full article.   Oxford Expression Technologies Since the early 1990’s baculoviruses have been used for producing complex proteins