The science of recombinant protein expression

Partners

 

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OET collaborates with Trenzyme so that both companies will be able to offer a full range of recombinant protein expression services across a variety of platforms including baculovirus, yeast, bacterial and mammalian systems.

 The collaboration offers exciting possibilities in the field of the rapidly developing BacMam system, in which baculoviruses are used for protein production in mammalian cell lines. The BacMam system increases the options available to improve both the yield and quality of recombinant proteins. It also has applications in therapeutic fields including the production of recombinant vaccines and gene delivery into human cells.
  Furthermore, the BacMam system fits perfectly to the Cross Organism Expression platform of Trenzyme allowing the fast and reliable screening of the best expression host for a given target protein in respect of timelines, yield and quality.

  Entelechon is a service provider in synthetic and molecular biology, whose main competencies include gene synthesis, bioinformatics, protein/protein modification analysis and molecular biology assay development and implementation.  Entelechon's success is ensured by their diverse team of experts that cover all aspects of a client’s project, so providing integrated solutions tailored to the client’s requirements.  OET and Entelechon collaborate to offer a joint “Gene to Protein” service.  Provide us with a general project concept and we will design a protocol, synthesise and optimise a gene and express your protein of interest using the Baculovirus expression system.

 

 

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OET collaborates with protein production experts ProteoNic BV. The companies have joined forces in the field of recombinant protein production technology with the aim of jointly offering a superior platform and services. Several projects combining ProteoNic’s UNic™ translation enhancement elements with OET’s flashBAC™ system have been initiated with a view to developing a protein production platform that leverages the benefits of both technologies.

 

 

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OET works closely with the Oxford Brookes University Insect Virus Research Group (IVRG) within the School of Biological & Molecular Sciences. The IVRG is co-located with OET in a purpose built suite of modern laboratories which are well equipped for many aspects of molecular biology and virology. The group also has access to all School facilities including a state-of-the-art microscopy suite for confocal and electron microscopy.

 

 

 

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European Collection of Cell Cultures (ECACC) is a provider of high quality cell cultures and associated services to industry and the academic research community. In partnership with ECACC, we offer a combined baculovirus expression service supporting scaled up production. ECACC's Bioprocessing Group specialises in developing scaled up animal cell culture processes complimenting OET's leading position in baculovirus expression techniques. Together, we can offer a complete service with the capability to produce recombinant protein in quantities from 1L to multiples of 100L as part of our baculoXPRESS service. 

 

 

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ParaTechs specialises in developing innovative biotechnological products and bringing them to market. ParaTechs is advancing the understanding of insect molecular biology for use in novel biotechnological applications by taking advantage of unique genes and proteins from insect parasites and pathogens. The collaboration will investigate the potential impact of expressing a Vankyrin gene in tandem with a foreign gene on the quality and yield of the foreign protein and to evaluate whether any benefits are enhanced by using the flashBAC system, which is already known to increase recombinant protein yields beyond those achieved using a conventional vector. This project will also compare flashBAC vectors expressing Vankyrin gene-fusions in ParaTechs Vankyrin-Enhanced cell lines, with standard insect cell lines.

 

 

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LifeSensors is a leading producer of tools that facilitate the study of the Ubiquitin Proteasome Pathway (UPP) and developer of novel technologies that use SUMO protein expression platform to overcome bottlenecks in protein production. Under the agreement with LifeSensors, the two companies will work together to incorporate a SUMO (small ubiquitin-like modifier) tag into the flashBAC system, and evaluate whether this increases the quality of protein produced. The use of SUMO as a fusion tag has been shown to dramatically increase yield and solubility of protein in more traditional systems. The two companies are hoping that SUMO will create an even more powerful flashBAC system.

 

 

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Protein Sciences Corporation (PSC) is dedicated to the development and commercialisation of innovative vaccines and biopharmaceuticals. OET teams up with PSC to offer complementary expertise in the use of baculovirus expression vectors for the production of safer and more effective human and veterinary vaccines, therapeutics and diagnostics.

 

 

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Oxford Expression Technologies is an active full member of the Oxfordshire BioScience Network (OBN). OBN is a business network which provides comprehensive support for Biotech and Medtech   companies in the Oxford and South-East England biocluster and beyond. OET participates in OBN's regular events including the regular BioTuesday meetings and Breakfast clubs , plus the annual BioTrinity conference, Europes fastest growing Biopartnering and Investment conference.

 

 

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